There are four ways to start Ansys Polyflow from Ansys Polyman:
Select a data file in the relevant simulation branch of the project tree, and then select the Programs/Polyflow menu item.
Programs → Polyflow
Select a data file in the relevant simulation branch of the project tree, and then type Ctrl-F.
Select a data file in the relevant simulation branch of the project tree, and then click the icon.
Select the Tools/Schedule simulations/Add menu item. See Scheduling a Simulation for details.
Ansys Polyflow will compute a solution for the selected data file and save the appropriate output files.