You access the Define Run dialog box from CFX-Solver Manager by clicking File > Define Run.
Under Solver Input File, ensure that the name of a CFX-Solver input
            file (with extension .def or .mdef) is
            specified.
The name will be set automatically if:
You have started CFX-Solver Manager using the Define Run action in CFX-Pre.
You have started CFX-Solver Manager from the command line using the
-interactiveand-defor-mdefoptions. For details, see Starting the CFX-Solver from the Command Line in the CFX-Solver Manager User's Guide.CFX-Solver input filenames must not contain spaces when run with an associated Ansys input file (.inp). Note that in CFX-Solver Manager, when specifying or editing the Solver Input File by typing from the keyboard, you must click
  to have the changes take effect.
In CFX-Solver Manager, if a multi-configuration definition or results file
                (*.mdef or *.mres, respectively) is
            selected as the CFX-Solver Input file, then the settings on the tabs described below can
            be made on a simulation-wide or per-configuration basis. This is done by choosing either
                Global Settings or a specific configuration name for the
                Edit Configuration option. Note that when global settings are
            made, they are inherited by all configurations. You can then override any setting for a
            specific configuration, but it is important to note that in this situation the remainder
            of the settings for the configuration will not be inherited from the global
            settings.
The tabs of the Define Run dialog box that can be configured are described in the following sections: