Scripting Using Iron Python
If you have existing VBScript/Javascript scripts use existing scripts them as much as possible by either embedding the test into the IronPython script or invoking them.
Translating a script in VBScript to IronPython
Read the chapter on translation and study the samples in that chapter as well as those in the appendix. For python syntax and the differences, the mini-cookbook chapter will also be useful.
Writing an IronPython script from scratch
Read through the scripting guide available from the product's help menu and translate the VBScript methods described to IronPython using the information provided in the chapter on translation. Studying the samples in the document will also prove helpful.
For python syntax and the differences, the mini-cookbook chapter will also be useful.
IronPython Script Execution Environment
Scripting using Embedded VBScript or JavaScript
Standalone IronPython and Desktop IronPython